Update J.P. Morgan Conference 2024

Multiple Sclerosis IVD: Improved Stability of REP-Antigen and Solid Data re Discrimination (i.a. Acute/Non-acute MS).

website under construction
Company

ORYX-Alpha identified a highly innovative translational project from Deutsches Krebsforschungszentrum, Heidelberg, in the field of Multiple Sclerosis and developed it in preclinical studies.
‍
The Company is the exclusive licensee of the respective translational project and related intellectual property and has established close collaborations with scientific institutions and leading experts.

ORYX-Alpha is headed by Dr. Bernard Huber, a molecular biologist and patent attorney who has been involved in setting up several biotech companies. The Company was founded in 2010 and is financed by highly motivated private investors.

TRANSLATIONAL
PROJECT

Prof. Harald zur Hausen, Nobel Laureate in Medicine 2008, discovered that bovine meat and milk consumption is correlated with Multiple Sclerosis1,2. Further research showed that bovine serum and milk as well as Multiple Sclerosis brains contain specific infectious agents, subsequently termed Bovine Meat and Milk Factors (BMMF)3-7.

BMMF are bioactive8 single-stranded circular DNA molecules encoding a conserved replication initiator protein (REP-protein)9,10. This protein is found in lesions of Multiple Sclerosis brains and Multiple Sclerosis patients show high antibody titers against it11.

Based on this discovery, ORYX-Alpha has developed an innovative Bridging ELISA to quantify the antibody levels against the REP-protein in serum.

The Bridging ELISA comprises a capture antigen and a tracer antigen, wherein the antigens are different REP-oligomers. It was validated and showed a Specificity of 92% and a Sensitivity of 80%12.

The Bridging ELISA allows the diagnosis of Multiple Sclerosis in serum. Further, our data indicates that it has also the potential for Early Diagnosis of Multiple Sclerosis, Disease Monitoring, Therapy Monitoring and as Companion Diagnostic11.

COLLABORATIONS

ORYX-Alpha has established close collaborations with leading scientific institutions and individuals. These include inter alia:

• Deutsches Krebsforschungszentrum, Heidelberg;
Prof. Harald zur Hausen and Prof. Ethel-Michele de Villiers

• Karolinska Institutet, Stockholm; and
Prof. Tomas Olsson and Prof. Hans Grönlund

• Technische Universität München, München.
Prof. Bernhard Hemmer and Prof. Ulrike Protzer

LEGAL

This website and the information contained herein are intended for Healthcare Professionals only and shall in no case be construed medical advice. Neither ORYX-Alpha nor its General Partner will respond to individual medical inquiries relating to patients.
Responsible Person
‍
ORYX-Alpha GmbH & Co. KG
Marktplatz 1, 85598 Baldham, Germany

Phone: +49 81 06 21 31 10
Email: info@oryxalpha.com
‍
Com. Reg. at Munich District Court: HRA 95183; VAT No. DE 280531561
General Partner

ORYX Verwaltungs GmbH
CEO Dr. Bernard Huber
Marktplatz 1, 85598 Badham, Germany

Phone: +49 81 06 21 31 10

Com. Reg. at Munich District Court: HRB 167985

© 2022 ORYX-Alpha GmbH & Co. KG

1 zur Hausen, What do breast and CRC cancers and MS have in common?, Nat Rev Clin Oncol 2015; 12(10): 569–570.

2 zur Hausen et al., Infectious agents in bovine red meat and milk and their potential role in cancer and other chronic diseases, Curr Top Microbiol Immunol 2017;407: 83–116.
‍
3 Funk et al., Isolation of protein-associated circular DNA from healthy cattle serum. Genome Announc 2014; 2(4): e00846-14.

4 Gunst et al.,Isolation of bacterial plasmid-related replication-associated circular DNA from a serum sample of a multiple sclerosis patient, Genome Announc 2014; 2(4): e00847-14.

5 Lamberto et al., Mycovirus-like DNA virus sequences from cattle serum and human brain and serum samples from multiple sclerosis patients, Genome Announc 2014; 2(4): e00848-14.

6 Falida et al., Isolation of two virus-like circular DNAs from commercially available milk samples, Genome Announc 2017; 5(17): e00266-17.

7 Whitley et al., Novel replicationcompetent circular DNA molecules from healthy cattle serum and milk and multiple sclerosis-affected human brain tissue, Genome Announc 2014; 2(4): e00849- 14.
‍
8 Eilebrecht et al., Expression and replication of virus-like circular DNA in human cells, Sci Rep 2018; 8(1): 2851.

9 de Villiers et al., A specific class of infectious agents isolated from bovine serum and dairy products and peritumoral colon cancer tissue, Emerg Microbes Infect 2019; 8(1): 1205–1218.

10 Kilic et al., Structural analysis of a replication protein encoded by a plasmid isolated from a multiplesclerosis patient, Acta Crystallogr D Struct Biol 2019; 75(5): 498–504.

11 Data on file at ORYX-Alpha, as of 21. February 2022.

12 Subgrouping of Multiple Sclerosis patients and healthy controls to the age of 53 years or younger; n total = 96 (n Multiple Sclerosis = 70 + n healthy controls = 26); data on file at ORYX-Alpha, as of 21. February 2022.